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KMID : 0363320130340020147
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Journal of Korean Oriental Internal Medicine
2013 Volume.34 No. 2 p.147 ~ p.154
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Effect of Jichul-hwan Extract on Gastric Contractility in Conscious Rats
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Kang Kyung
Yoon Sang-Hyub
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Abstract
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Objectives : The aims of this study was to find out whether Jichul-hwan (JCH) extract has an effect on gastric contractility in conscious rats by using a force transducer implanted in the body of the stomach.
Methods : The force transducer (model: F-081S, Starmedical, JAPAN) was implanted to the exterior wall of the stomach
body in rats. The gastric contractility was measured 30 minutes before and after administration of JCH (110.1 mg/kg). The
control group was administrated with normal saline instead of JCH to compare the effect of JCH. The gastric contractility of
the control group (normal saline: NS) was also measured 30 minutes before and after administration of NS.
Results : The ratio of gastric contractility between before and after medication by JCH was 1.707±0.731, and with NS was
0.701±0.541. The gastric motility increased by JCH was significantly higher than NS.
Conclusions : JCH extract increases gastric contractility in conscious rats. We could expect that this drug would be
effective in the treatment of functional dyspepsia or post-surgical gastroparesis.
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KEYWORD
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Jichul-hwan, force transducer, conscious rats, gastric contractility
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